Using Gene Expression Noise to Understand Gene Regulation
نویسندگان
چکیده
منابع مشابه
Using gene expression noise to understand gene regulation.
Phenotypic variation is ubiquitous in biology and is often traceable to underlying genetic and environmental variation. However, even genetically identical cells in identical environments display variable phenotypes. Stochastic gene expression, or gene expression "noise," has been suggested as a major source of this variability, and its physiological consequences have been topics of intense res...
متن کاملUsing Synthetic Biology to Understand the Evolution of Gene Expression
The evolution of phenotype is often based on changes in gene expression rather than changes in protein-coding sequence. Gene expression is controlled by complex networks of interacting regulators that act through a variety of biochemical mechanisms. Perturbation of these networks can have profound effects on the fitness of organisms. This highlights an important challenge: the investigation of ...
متن کاملThe Evaluation of GJB2 Gene Expression in the Cochlear Tissue Exposed to White Noise
Introduction: One of the most important complications of exposure to noises is changes in the gene expression patterns. Irreversible damage to the inner ear, such as noise-induced hearing loss (NIHL), is caused by tissue damage and changes in the gene expressions in the auditory system. Changes in the GJB2 gene expression pattern lead to autosomal deafness at different loci. The present study a...
متن کاملGene Regulation: Stable Noise
Transcriptional regulation is noisy, yet despite this variability, embryonic development reproducibly generates form and function. Recent work demonstrates that patterns of transcriptional activity in embryos are stably inherited through mitosis. These observations have implications for how accuracy arises in development.
متن کاملForecasting copper price using gene expression programming
Forecasting the prices of metals is important in many aspects of economics. Metal prices are also vital variables in financial models for revenue evaluation, which forms the basis of an effective payment regime using resource policymakers. According to the severe changes of the metal prices in the recent years, the classic estimation methods cannot correctly estimate the volatility. In order to...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science
سال: 2012
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1216379